反应详情

温度

60 °C

6-Methoxycarbonylmethylsulfanyl-5-nitro-nicotinic acid methyl ester (1.0 g) in acetic acid (50 mL) was treated with iron powder (10 g) and the mixture was stirred and heated at 60° C. for 1 hour, cooled and filtered. The filtrate was evaporated, treated with sodium bicarbonate solution and extracted with warm chloroform. It was dried (anhydrous sodium sulfate) and evaporated to give a white solid (0.85 g).

1. temperaturecooled
2. filtrationfiltered
3. customThe filtrate was evaporated
4. additiontreated with sodium bicarbonate solution
5. extractionextracted with warm chloroform
6. dry with materialIt was dried (anhydrous sodium sulfate)
7. customevaporated