HuagongsheHuagongshe Chemie-Druckbericht · Nur für Forschungszwecke
Isobutyl chloroformate → 7-(hydroxymethyl)-1H-pyrido[2,3-b][1,4]thiazin-2(3H)-one
Beteiligte Stoffe
| Rolle | Name | HCID | Einwaage |
|---|---|---|---|
| Edukt | Isobutyl chloroformate | HCID 62365 | — |
| Edukt | Sodium borohydride | HCID 4311764 | — |
| Edukt | 2,3-Dihydro-2-oxo-1H-pyrido[2,3-b][1,4]thiazine-7-carboxylic acid | HCID 21873692 | — |
| Produkt | 7-(hydroxymethyl)-1H-pyrido[2,3-b][1,4]thiazin-2(3H)-one | HCID 21873728 | 56,2% |
Reaktionsschritte
2-Oxo-2,3-dihydro-1H-pyrido[2,3-b][1,4]thiazine-7-carboxylic acid (2.48 g) was reacted with iso-butylchloroformate and sodium borohydride by the method of Preparation (14b) to afford a solid (1.3 g), after recrystallisation from chloroform-methanol (9:1). MS (ES) m/e 197 (M+H)+.
Herkunft & Nachweise
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patentnummer | US07618959B2 |
| Quelldatensatz | uspto-grants-2009_11 |
| ORD ID | ord-43de51b122d34dc28ddbfadd8580d79f |
| Quellennotiz | uspto-grants-2009_11 |