HRID1435862

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID62365

Isobutyl chloroformate

C5H9ClO2

HCID4311764

Sodium borohydride (Na(BH4))

H4BNa

HCID21873692

2,3-Dihydro-2-oxo-1H-pyrido[2,3-b][1,4]thiazine-7-carboxylic acid

C8H6N2O3S

PRODUCTS

生成物

HCID21873728

7-(Hydroxymethyl)-1H-pyrido[2,3-b][1,4]thiazin-2(3H)-one

C8H8N2O2S

收率 56.2%

PROCEDURE

实验过程

2-Oxo-2,3-dihydro-1H-pyrido[2,3-b][1,4]thiazine-7-carboxylic acid (2.48 g) was reacted with iso-butylchloroformate and sodium borohydride by the method of Preparation (14b) to afford a solid (1.3 g), after recrystallisation from chloroform-methanol (9:1). MS (ES) m/e 197 (M+H)+.