反应详情

To a stirred solution of 5-bromo-2-(bromomethyl)pyridine (0.70 g, 2.12 mmole), in EtOH (50 mL) at 60° C. was added KCN (0.21 g, 3.18 mmole) in H2O (3 mL). After 1.5 h, the reaction contents were cooled to RT and concentrated under vacuum. The aqueous residue was dissolved in EtOAc and washed with H20, and dried over Na2SO4. Concentration under vacuum and purification on silica (EtOAc) afforded the title compound (0.38 g, 65%) as light yellow solid: LC-MS (ES) m/e 277 (M+H)+.

1. customthe reaction contents
2. concentrationconcentrated under vacuum
3. dissolutionThe aqueous residue was dissolved in EtOAc
4. washwashed with H20
5. dry with materialdried over Na2SO4
6. concentrationConcentration
7. customunder vacuum and purification on silica (EtOAc)