Sodium Hydroxide → HCID 9825028, compound

HRID 1435883Notes

Reaction equation

HRID 1435883 reaction equation
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([S:8][C:9]2[C:10]3[C:27]([S:28]([CH3:31])(=[O:30])=[O:29])=[CH:26][CH:25]=[N:24][C:11]=3[N:12]3[C:17]=2[CH:16]([CH2:18][C:19]([O:21]CC)=[O:20])[CH2:15][CH2:14][CH2:13]3)=[CH:4][CH:3]=1.[OH-].[Na+]>>[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([S:8][C:9]2[C:10]3[C:27]([S:28]([CH3:31])(=[O:30])=[O:29])=[CH:26][CH:25]=[N:24][C:11]=3[N:12]3[C:17]=2[CH:16]([CH2:18][C:19]([OH:21])=[O:20])[CH2:15][CH2:14][CH2:13]3)=[CH:4][CH:3]=1

Participants

3

Reactant 2

HCID 14798Sodium HydroxideHCID 91276850HCID 91276850, compound

Product 1

HCID 9825028HCID 9825028, compound

Procedure

To the compound of Step 10 dissolved in a 1/1 mixture of TBF-MeOH was added 1N NaOH. After a period of 18 h at room temperature, the reaction mixture was partitioned between saturated NH4Cl and EtOAc. The organic phase was separated, dried over Na2SO4 and evaporated to provide the title compound.

Workup

  1. customthe reaction mixture was partitioned between saturated NH4Cl and EtOAc
  2. customThe organic phase was separated
  3. dry with materialdried over Na2SO4
  4. customevaporated

Sources & evidence

ORD record
ord-3689e01dc24043e28b7049e948baa302
Source dataset
uspto-grants-2009_11
Patent number
US07618979B2

Reaction notes

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