Hydrochloric Acid → HCID 131727767, compound

HRID 1435959Notes

Reaction equation

HRID 1435959 reaction equation
[CH3:1][O:2][C:3]1[CH:8]=[C:7]([CH2:9][NH:10][CH2:11][CH2:12][CH2:13][NH:14][CH2:15][CH2:16][CH2:17][CH2:18][NH:19][CH2:20][CH2:21][CH2:22][NH:23][CH2:24][C:25]2[CH:30]=[CH:29][C:28]([OH:31])=[C:27]([O:32][CH3:33])[CH:26]=2)[CH:6]=[CH:5][C:4]=1[OH:34].C(OC([N:42]1[CH2:47][CH2:46][C:45]2[N:48]([C:57](C)(C)[O:58][SiH2]C(C)(C)C)[C:49]([C:51]3[CH:56]=[CH:55][N:54]=[CH:53][CH:52]=3)=[CH:50][C:44]=2[C:43]1=[O:66])=O)(C)(C)C.[ClH:67]>O1CCOCC1>[CH3:33][O:32][C:27]1[CH:26]=[C:25]([CH2:24][NH:23][CH2:22][CH2:21][CH2:20][NH:19][CH2:18][CH2:17][CH2:16][CH2:15][NH:14][CH2:13][CH2:12][CH2:11][NH:10][CH2:9][C:7]2[CH:6]=[CH:5][C:4]([OH:34])=[C:3]([O:2][CH3:1])[CH:8]=2)[CH:30]=[CH:29][C:28]=1[OH:31].[ClH:67].[OH:58][CH2:57][N:48]1[C:45]2[CH2:46][CH2:47][NH:42][C:43](=[O:66])[C:44]=2[CH:50]=[C:49]1[C:51]1[CH:52]=[CH:53][N:54]=[CH:55][CH:56]=1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 131727769HCID 131727769, compound

Product 1

HCID 131727767HCID 131727767, compound

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent

Procedure

A solution of 50 mg of DL-6-(tert-butyl-dimethyl-silanyloxymethyl)-4-oxo-2-pyridin-4-yl 1,4,6,7-tetrahydro-pyrrolo[3,2-c]pyridine-5-carboxylic acid tert-butyl ester in 5 mL of 4M HCl in dioxane was stirred for 4 hours at room temperature. The solution was concentrated and the title compound recovered.

Workup

  1. concentrationThe solution was concentrated
  2. customthe title compound recovered

Sources & evidence

ORD record
ord-084b1e3e8b89421b81a6209e6ddc3889
Source dataset
uspto-grants-2009_11
Patent number
US07618982B2

Reaction notes

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