tert-Butyl (3S)-3-hydroxypyrrolidine-1-carboxylate → HCID 68875035, compound

HRID 1435968Notes

Reaction equation

HRID 1435968 reaction equation
C(OC([N:8]1[CH2:12][CH2:11][C@H:10]([OH:13])[CH2:9]1)=O)(C)(C)C.[NH2:14][C:15]1[C:24]2[C:19](=[CH:20][C:21](O)=[CH:22][CH:23]=2)[CH:18]=[CH:17][N:16]=1>>[NH:8]1[CH2:12][CH2:11][C@H:10]([O:13][C:21]2[CH:20]=[C:19]3[C:24](=[CH:23][CH:22]=2)[C:15]([NH2:14])=[N:16][CH:17]=[CH:18]3)[CH2:9]1

Participants

3

Reactant 2

HCID 854055tert-Butyl (3S)-3-hydroxypyrrolidine-1-carboxylateHCID 1357539911-Aminoisoquinolin-6-ol

Product 1

HCID 68875035HCID 68875035, compound

Procedure

This compound was prepared from (S)-3-hydroxypyrrolidine-1-carboxylic acid tert-butyl ester (195 mg, 1.04 mmol) and 1-amino-6-hydroxyisoquinoline (200 mg, 1.25 mmol) by the Mitsunobu procedure described in 3C, subsequent Boc deprotection according to procedure described in 3D gave (S)-6-(pyrrolidin-3-yloxy)-isoquinolin-1-ylamine, El-MS: m/z=230.3 [M+H]+.

Sources & evidence

ORD record
ord-c08d00961397459fa951d3dcd15037f1
Source dataset
uspto-grants-2009_11
Patent number
US07618985B2

Reaction notes

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