(S)-6-(piperidin-3-yloxy)-2H-isoquinolin-1-one → 7-Methyl-6-(piperidin-3-yloxy)-2H-isoquinolin-1-one

HRID 1436004Notes

Reaction equation

HRID 1436004 reaction equation
[NH:1]1[CH2:6][CH2:5][CH2:4][C@H:3]([O:7][C:8]2[CH:9]=[C:10]3[C:15](=[CH:16][CH:17]=2)[C:14](=[O:18])[NH:13][CH:12]=[CH:11]3)[CH2:2]1.[C:19](OC(N1CCC[C@@H](OS(C)(=O)=O)C1)=O)(C)(C)C.OC1C=C2C(=CC=1C)C(=O)NC=C2>>[CH3:19][C:17]1[CH:16]=[C:15]2[C:10]([CH:11]=[CH:12][NH:13][C:14]2=[O:18])=[CH:9][C:8]=1[O:7][CH:3]1[CH2:4][CH2:5][CH2:6][NH:1][CH2:2]1

Participants

4

Reactant 3

HCID 16124479(S)-6-(piperidin-3-yloxy)-2H-isoquinolin-1-oneHCID 29939737tert-Butyl (3R)-3-[(methanesulfonyl)oxy]piperidine-1-carboxylateHCID 688755126-Hydroxy-7-methylisoquinolin-1(2H)-one

Product 1

HCID 576524217-Methyl-6-(piperidin-3-yloxy)-2H-isoquinolin-1-one

Procedure

Prepared according to Example 24C and 24D using (R)-3-methanesulphonyloxy-piperidine-1-carboxylic acid tert-butyl ester and 6-hydroxy-7-methyl-2H-isoquinolin-1-one to afford 7-Methyl-6-(piperidin-3-yloxy)-2H-isoquinolin-1-one El-MS: m/z=259.1 [M+H]+.

Workup

  1. customPrepared

Sources & evidence

ORD record
ord-a02de5b066be46a7935f5f3d13176a41
Source dataset
uspto-grants-2009_11
Patent number
US07618985B2

Reaction notes

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