HCID 68875474, compound → HCID 68875608, compound

Participants

Reaction Steps

A suspension of 6-methoxy-4-methyl-2H-isoquinolin-1-one (215 mg, 1.1 mmol) in 5N hydrochloric acid (1 ml) was was irradiated in a microwave at 180° C. for 40 minutes. After removing solvent in vacuo the crude residue was purified by flash chromatography on silica (eluent: 1% methanol in DCM) to give 6-hydroxy-4-methyl-2H-isoquinolin-1-one (130 mg, 67%)., El-MS: m/z=174.3 [M-H]+.

Provenance & Evidence