HCID 68875474, compound → HCID 68875608, compound

HRID 1436008Notes

Reaction equation

HRID 1436008 reaction equation
C[O:2][C:3]1[CH:4]=[C:5]2[C:10](=[CH:11][CH:12]=1)[C:9](=[O:13])[NH:8][CH:7]=[C:6]2[CH3:14]>Cl>[OH:2][C:3]1[CH:4]=[C:5]2[C:10](=[CH:11][CH:12]=1)[C:9](=[O:13])[NH:8][CH:7]=[C:6]2[CH3:14]

Participants

3

Reactant 1

HCID 68875474HCID 68875474, compound

Product 1

HCID 68875608HCID 68875608, compoundYield 67.5%

Reagents, catalysts & solvents 1

HCID 313Hydrochloric AcidSolvent

Procedure

A suspension of 6-methoxy-4-methyl-2H-isoquinolin-1-one (215 mg, 1.1 mmol) in 5N hydrochloric acid (1 ml) was was irradiated in a microwave at 180° C. for 40 minutes. After removing solvent in vacuo the crude residue was purified by flash chromatography on silica (eluent: 1% methanol in DCM) to give 6-hydroxy-4-methyl-2H-isoquinolin-1-one (130 mg, 67%)., El-MS: m/z=174.3 [M-H]+.

Workup

  1. customwas was irradiated in a microwave at 180° C. for 40 minutes
  2. customAfter removing solvent in vacuo the crude residue
  3. customwas purified by flash chromatography on silica (eluent: 1% methanol in DCM)

Sources & evidence

ORD record
ord-3967c06ffe0848e39d8fad51b8618947
Source dataset
uspto-grants-2009_11
Patent number
US07618985B2

Reaction notes

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