HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1436012Generated: October 26, 2026
Phosphorus oxychloride → 5-Bromo-1-chloro-6-methoxyisoquinoline
https://huagongshe.com/reaction/1436012
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Phosphorus oxychloride | HCID 24813 | — |
| Reactant | 5-bromo-6-methoxyisoquinoline-N-oxide hydrochloride | HCID 68878024 | — |
| Product | 5-Bromo-1-chloro-6-methoxyisoquinoline | HCID 57956460 | 110.1% |
Reaction Steps
POCl3 (6.5 ml) was added to the 5-bromo-6-methoxyisoquinoline-N-oxide hydrochloride (1.22 g) and the mixture heated at 90° C. for 6 h. Excess POCl3 was removed in vacuo and the remaining solid washed with water, filtered and dried in vacuo to give 5-bromo-1-chloro-6-methoxyisoquinoline (1.26 g).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US07618985B2 |
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| Source dataset | uspto-grants-2009_11 |
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| ORD ID | ord-f1c98be2325144308728bc9ba854eb7e |
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| Source note | uspto-grants-2009_11 |
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