反应详情

温度

90 °C

POCl3 (6.5 ml) was added to the 5-bromo-6-methoxyisoquinoline-N-oxide hydrochloride (1.22 g) and the mixture heated at 90° C. for 6 h. Excess POCl3 was removed in vacuo and the remaining solid washed with water, filtered and dried in vacuo to give 5-bromo-1-chloro-6-methoxyisoquinoline (1.26 g).

1. customExcess POCl3 was removed in vacuo
2. washthe remaining solid washed with water
3. filtrationfiltered
4. customdried in vacuo