HRID1436022

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID4233041

3-Boc-aminopiperidine

C10H20N2O2

HCID14580058

4-Bromo-5-isoquinolinesulfonyl chloride

C9H5BrClNO2S

PRODUCTS

生成物

HCID313

Hydrochloric Acid

ClH

结构：NC1CCCN(S(=O)(=O)c2cccc3cncc(Br)c23)C1

HCID67242500

未命名化合物

结构：CC(C)(C)OC(=O)NC1CCCN(S(=O)(=O)c2cccc3cncc(Br)c23)C1

HCID67242812

未命名化合物

PROCEDURE

实验过程

(R/S)-3-(tert-Butoxycarbonylamino)-1-(4-bromo-5-isoquinolinesulfonyl)-piperidine (Intermediate 2) is prepared from 4-bromo-5-isoquinolinesulfonyl chloride and 3-(tert-butoxycarbonylamino)piperidine (AstaTech) according to the method described in Example 1, Step A, and then used in the method of Example 1, Step B in a similar manner to obtain the title compound as hydrochloride.

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-a1213e5e8c564617990446db1b4084bb
来源数据集: uspto-grants-2009_11
DOI: 10.6084/m9.figshare.5104873.v1
专利: US07618984B2
来源说明: uspto-grants-2009_11

反应 SMILES

[Br:1][C:2]1[C:11]2[C:10]([S:12]([Cl:15])(=[O:14])=[O:13])=[CH:9][CH:8]=[CH:7][C:6]=2[CH:5]=[N:4][CH:3]=1.[C:16]([O:20][C:21]([NH:23][CH:24]1[CH2:29][CH2:28][CH2:27][NH:26][CH2:25]1)=[O:22])([CH3:19])([CH3:18])[CH3:17]>>[C:16]([O:20][C:21]([NH:23][CH:24]1[CH2:29][CH2:28][CH2:27][N:26]([S:12]([C:10]2[C:11]3[C:2]([Br:1])=[CH:3][N:4]=[CH:5][C:6]=3[CH:7]=[CH:8][CH:9]=2)(=[O:14])=[O:13])[CH2:25]1)=[O:22])([CH3:19])([CH3:17])[CH3:18].[NH2:23][CH:24]1[CH2:29][CH2:28][CH2:27][N:26]([S:12]([C:10]2[C:11]3[C:2]([Br:1])=[CH:3][N:4]=[CH:5][C:6]=3[CH:7]=[CH:8][CH:9]=2)(=[O:14])=[O:13])[CH2:25]1.[ClH:15]