Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Hydrochloride methanol | HCID 21893726 | — |
| Reactant | 3-(Tert-butoxycarbonylamino)-1-(4-bromo-1-methoxy-5-isoquinolinesulfonyl)pyrrolidine | HCID 67243741 | — |
| Product | Hydrochloric Acid | HCID 313 | — |
| Product | HCID 178507921 | HCID 178507921 | — |
Reaction Steps
Intermediate 4 (25 mg) obtained in Example 6, Step B is added with 10% hydrogen chloride/methanol (10 ml), and the mixture is stirred at 50° C. for 50 hours. The solvent is evaporated under reduced pressure to obtain the title compound as hydrochloride (13 mg (predictive yield)).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US07618984B2 |
|---|
| Source dataset | uspto-grants-2009_11 |
|---|
| ORD ID | ord-f77db038b47c49c7828719307512f5e5 |
|---|
| Source note | uspto-grants-2009_11 |
|---|
