Hydrochloride methanol → Hydrochloric Acid

HRID 1436025Notes

Reaction equation

HRID 1436025 reaction equation
C(OC([NH:8][CH:9]1[CH2:13][CH2:12][N:11]([S:14]([C:17]2[C:18]3[C:19]([Br:29])=[CH:20][N:21]=[C:22]([O:27]C)[C:23]=3[CH:24]=[CH:25][CH:26]=2)(=[O:16])=[O:15])[CH2:10]1)=O)(C)(C)C.[ClH:30].CO>>[NH2:8][CH:9]1[CH2:13][CH2:12][N:11]([S:14]([C:17]2[C:18]3[C:19]([Br:29])=[CH:20][N:21]=[C:22]([OH:27])[C:23]=3[CH:24]=[CH:25][CH:26]=2)(=[O:15])=[O:16])[CH2:10]1.[ClH:30]

Participants

4

Reactant 2

HCID 21893726Hydrochloride methanolHCID 672437413-(Tert-butoxycarbonylamino)-1-(4-bromo-1-methoxy-5-isoquinolinesulfonyl)pyrrolidine

Product 2

HCID 313Hydrochloric AcidHCID 178507921HCID 178507921, compound

Conditions

Temperature
50 °C

Procedure

Intermediate 4 (25 mg) obtained in Example 6, Step B is added with 10% hydrogen chloride/methanol (10 ml), and the mixture is stirred at 50° C. for 50 hours. The solvent is evaporated under reduced pressure to obtain the title compound as hydrochloride (13 mg (predictive yield)).

Workup

  1. customThe solvent is evaporated under reduced pressure

Sources & evidence

ORD record
ord-f77db038b47c49c7828719307512f5e5
Source dataset
uspto-grants-2009_11
Patent number
US07618984B2

Reaction notes

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