反应详情

温度

100 °C

A suspension of Intermediate 1 (137 mg) obtained in Example 1, Step A, tris(dibenzylideneacetone)dipalladium(0) (55 mg, Aldrich), (±)-2,2′-bis(diphenylphosphino)-1,1′-binaphthyl (37 mg, Aldrich), tert-butyl carbamate (70 mg, Aldrich), and cesium carbonate (196 mg, Aldrich) in toluene (5 ml) is stirred at 100° C. for 15 hours. The reaction mixture is cooled to room temperature, and then added with ethyl acetate (5 ml), and the insoluble matters are removed by filtration through Celite. The solvent is evaporated under reduced pressure, and the residue is purified by silica gel chromatography (n-hexane:ethyl acetate=1:1) to obtain the title compound (48 mg (predictive yield)).

1. temperatureThe reaction mixture is cooled to room temperature
2. customthe insoluble matters are removed by filtration through Celite
3. customThe solvent is evaporated under reduced pressure
4. customthe residue is purified by silica gel chromatography (n-hexane:ethyl acetate=1:1)