(r/s)-3-(Tert-butoxycarbonylamino)-1-(4-bromo-5-isoquinolinesulfonyl)pyrrolidine → Hydrochloric Acid

HRID 1436037Notes

Reaction equation

HRID 1436037 reaction equation
C(OC([NH:8][C@H:9]1[CH2:13][CH2:12][N:11]([S:14]([C:17]2[C:18]3[C:19]([Cl:27])=[CH:20][N:21]=[CH:22][C:23]=3[CH:24]=[CH:25][CH:26]=2)(=[O:16])=[O:15])[CH2:10]1)=O)(C)(C)C.C([O:32]C(NC1CCN(S(C2C3C(Br)=CN=CC=3C=CC=2)(=O)=O)C1)=O)(C)(C)C>>[NH2:8][C@H:9]1[CH2:13][CH2:12][N:11]([S:14]([C:17]2[C:18]3[C:19]([Cl:27])=[CH:20][N:21]=[C:22]([OH:32])[C:23]=3[CH:24]=[CH:25][CH:26]=2)(=[O:16])=[O:15])[CH2:10]1.[ClH:27]

Participants

4

Reactant 2

HCID 67242856(r/s)-3-(Tert-butoxycarbonylamino)-1-(4-bromo-5-isoquinolinesulfonyl)pyrrolidineHCID 67244997HCID 67244997, compound

Product 2

HCID 313Hydrochloric AcidHCID 178511750HCID 178511750, compound

Procedure

Intermediate 16a was used in the method of Example 6, Step A instead of Intermediate 1, then the resultant was used in the method of Step B in a similar manner, and then the title compound was obtained as hydrochloride according to the method described in Example 7.

Sources & evidence

ORD record
ord-bc850c3383ba4bc9a6760e9f00ab1f08
Source dataset
uspto-grants-2009_11
Patent number
US07618984B2

Reaction notes

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