HuagongsheHuagongshe Chemistry Print Report · For research reference only
tert-butyl N-(pyrrolidin-3-yl)carbamate → Hydrochloric Acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | tert-butyl N-(pyrrolidin-3-yl)carbamate | HCID 2757234 | — |
| Reactant | tert-Butyl methyl((3R)-pyrrolidin-3-yl)carbamate | HCID 7019173 | — |
| Reactant | 4-Fluoroisoquinoline-5-sulfonylchloride | HCID 11856547 | — |
| Reactant | 4-Bromo-5-isoquinolinesulfonyl chloride | HCID 14580058 | — |
| Product | Hydrochloric Acid | HCID 313 | — |
| Product | (R)-3-[N-(tert-Butoxycarbonyl)-N-methylamino]-1-(4-fluoro-5-isoquinolinesulfonyl)pyrrolidine | HCID 67243108 | — |
| Product | (R)-1-(4-Fluoro-5-isoquinolinesulfonyl)-3-(methylamino)pyrrolidine | HCID 67243602 | — |
Reaction Steps
(R)-3-[N-(tert-Butoxycarbonyl)-N-methylamino]-1-(4-fluoro-5-isoquinolinesulfonyl)pyrrolidine (Intermediate 22b) is prepared by using 4-fluoro-5-isoquinolinesulfonyl chloride and (R)-3-[N-(tert-butoxycarbonyl)-N-methylamino]pyrrolidine in the method of Example 31, Step A instead of 4-bromo-5-isoquinolinesulfonyl chloride and 3-(tert-butoxycarbonylamino)pyrrolidine, respectively, and then used in the method of Example 31, Step B in a similar manner to obtain the title compound as hydrochloride.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07618984B2 |
| Source dataset | uspto-grants-2009_11 |
| ORD ID | ord-bc4e79f5be684990aa1a380f431a8c91 |
| Source note | uspto-grants-2009_11 |