HRID1436044

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID2757234

未命名化合物

HCID7019173

tert-Butyl methyl[(3R)-pyrrolidin-3-yl]carbamate

C10H20N2O2

HCID11856547

4-fluoroisoquinoline-5-sulfonyl Chloride

C9H5ClFNO2S

HCID14580058

4-Bromo-5-isoquinolinesulfonyl chloride

C9H5BrClNO2S

PRODUCTS

生成物

HCID313

Hydrochloric Acid

ClH

结构：CN(C(=O)OC(C)(C)C)[C@@H]1CCN(S(=O)(=O)c2cccc3cncc(F)c23)C1

HCID67243108

未命名化合物

结构：CN[C@@H]1CCN(S(=O)(=O)c2cccc3cncc(F)c23)C1

HCID67243602

未命名化合物

PROCEDURE

实验过程

(R)-3-[N-(tert-Butoxycarbonyl)-N-methylamino]-1-(4-fluoro-5-isoquinolinesulfonyl)pyrrolidine (Intermediate 22b) is prepared by using 4-fluoro-5-isoquinolinesulfonyl chloride and (R)-3-[N-(tert-butoxycarbonyl)-N-methylamino]pyrrolidine in the method of Example 31, Step A instead of 4-bromo-5-isoquinolinesulfonyl chloride and 3-(tert-butoxycarbonylamino)pyrrolidine, respectively, and then used in the method of Example 31, Step B in a similar manner to obtain the title compound as hydrochloride.

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-bc4e79f5be684990aa1a380f431a8c91
来源数据集: uspto-grants-2009_11
DOI: 10.6084/m9.figshare.5104873.v1
专利: US07618984B2
来源说明: uspto-grants-2009_11

反应 SMILES

[F:1][C:2]1[C:11]2[C:10]([S:12]([Cl:15])(=[O:14])=[O:13])=[CH:9][CH:8]=[CH:7][C:6]=2[CH:5]=[N:4][CH:3]=1.[C:16]([O:20][C:21]([N:23]([C@@H:25]1[CH2:29][CH2:28][NH:27][CH2:26]1)[CH3:24])=[O:22])([CH3:19])([CH3:18])[CH3:17].BrC1C2C(S(Cl)(=O)=O)=CC=CC=2C=NC=1.C(O[C:50]([NH:52][CH:53]1[CH2:57][CH2:56][NH:55][CH2:54]1)=O)(C)(C)C>>[C:16]([O:20][C:21]([N:23]([C@@H:25]1[CH2:29][CH2:28][N:27]([S:12]([C:10]2[C:11]3[C:2]([F:1])=[CH:3][N:4]=[CH:5][C:6]=3[CH:7]=[CH:8][CH:9]=2)(=[O:14])=[O:13])[CH2:26]1)[CH3:24])=[O:22])([CH3:19])([CH3:17])[CH3:18].[F:1][C:2]1[C:11]2[C:10]([S:12]([N:55]3[CH2:56][CH2:57][C@@H:53]([NH:52][CH3:50])[CH2:54]3)(=[O:14])=[O:13])=[CH:9][CH:8]=[CH:7][C:6]=2[CH:5]=[N:4][CH:3]=1.[ClH:15]