Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Hydrochloride methanol | HCID 21893726 | — |
| Reactant | 3-[n-(Tert-butoxycarbonyl)-n-methylamino]-1-(1-chloro-4-bromo-5-isoquinolinesulfonyl)pyrrolidine | HCID 87322379 | — |
| Product | Hydrochloric Acid | HCID 313 | — |
| Product | HCID 178482263 | HCID 178482263 | — |
Reaction Steps
Intermediate 24 (168 mg) obtained in Step A mentioned above is added with 10% hydrogen chloride/methanol (4 ml), and the mixture is stirred at 60° C. for 30 hours. The solvent is evaporated under reduced pressure to obtain the title compound as hydrochloride (123 mg (predictive yield)).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US07618984B2 |
|---|
| Source dataset | uspto-grants-2009_11 |
|---|
| ORD ID | ord-1296dde748b24164816e400c4603e5d6 |
|---|
| Source note | uspto-grants-2009_11 |
|---|
