Hydrochloride methanol → Hydrochloric Acid

HRID 1436045Notes

Reaction equation

HRID 1436045 reaction equation
C(OC([N:8]([CH:10]1[CH2:14][CH2:13][N:12]([S:15]([C:18]2[C:19]3[C:20]([Br:29])=[CH:21][N:22]=[C:23]([Cl:28])[C:24]=3[CH:25]=[CH:26][CH:27]=2)(=[O:17])=[O:16])[CH2:11]1)[CH3:9])=O)(C)(C)C.Cl.C[OH:32]>>[OH:32][C:23]1[C:24]2[CH:25]=[CH:26][CH:27]=[C:18]([S:15]([N:12]3[CH2:13][CH2:14][CH:10]([NH:8][CH3:9])[CH2:11]3)(=[O:17])=[O:16])[C:19]=2[C:20]([Br:29])=[CH:21][N:22]=1.[ClH:28]

Participants

4

Reactant 2

HCID 21893726Hydrochloride methanolHCID 873223793-[n-(Tert-butoxycarbonyl)-n-methylamino]-1-(1-chloro-4-bromo-5-isoquinolinesulfonyl)pyrrolidine

Product 2

HCID 313Hydrochloric AcidHCID 178482263HCID 178482263, compound

Conditions

Temperature
60 °C

Procedure

Intermediate 24 (168 mg) obtained in Step A mentioned above is added with 10% hydrogen chloride/methanol (4 ml), and the mixture is stirred at 60° C. for 30 hours. The solvent is evaporated under reduced pressure to obtain the title compound as hydrochloride (123 mg (predictive yield)).

Workup

  1. customThe solvent is evaporated under reduced pressure

Sources & evidence

ORD record
ord-1296dde748b24164816e400c4603e5d6
Source dataset
uspto-grants-2009_11
Patent number
US07618984B2

Reaction notes

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