HRID1436047

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID2761404

tert-Butyl methyl(pyrrolidin-3-yl)carbamate

C10H20N2O2

HCID7019173

tert-Butyl methyl[(3R)-pyrrolidin-3-yl]carbamate

C10H20N2O2

HCID76851489

未命名化合物

HCID76851490

未命名化合物

PRODUCTS

生成物

HCID313

Hydrochloric Acid

ClH

结构：CN(C(=O)OC(C)(C)C)[C@@H]1CCN(S(=O)(=O)c2cccc3c(Cl)ncc(Cl)c23)C1

HCID86613859

未命名化合物

结构：CN[C@@H]1CCN(S(=O)(=O)c2cccc3c(O)ncc(Cl)c23)C1

HCID178484868

未命名化合物

PROCEDURE

实验过程

(R)-3-[N-(tert-Butoxycarbonyl)-N-methylamino]-1-(1,4-dichloro-5-isoquinolinesulfonyl)pyrrolidine (Intermediate 25b) was prepared by using 1,4-dichloro-5-isoquinolinesulfonyl chloride and (R)-3-[N-(tert-butoxycarbonyl)-N-methylamino]pyrrolidine in the method of Example 35, Step A instead of 1-chloro-4-bromo-5-isoquinolinesulfonyl chloride and 3-[N-(tert-butoxycarbonyl)-N-methylamino]pyrrolidine, respectively, and then used in the method of Example 35, Step B in a similar manner to obtain the title compound as hydrochloride.

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-08437f3b2327445288be0e2bcb7c5e5a
来源数据集: uspto-grants-2009_11
DOI: 10.6084/m9.figshare.5104873.v1
专利: US07618984B2
来源说明: uspto-grants-2009_11

反应 SMILES

[Cl:1][C:2]1[C:11]2[CH:10]=[CH:9][CH:8]=[C:7]([S:12](Cl)(=[O:14])=[O:13])[C:6]=2[C:5]([Cl:16])=[CH:4][N:3]=1.[C:17]([O:21][C:22]([N:24]([C@@H:26]1[CH2:30][CH2:29][NH:28][CH2:27]1)[CH3:25])=[O:23])([CH3:20])([CH3:19])[CH3:18].[Cl:31]C1C2C=CC=C(S(Cl)(=O)=[O:43])C=2C(Br)=CN=1.C(O[C:52]([N:54]([CH:56]1[CH2:60][CH2:59][NH:58][CH2:57]1)C)=O)(C)(C)C>>[C:17]([O:21][C:22]([N:24]([C@@H:26]1[CH2:30][CH2:29][N:28]([S:12]([C:7]2[C:6]3[C:5]([Cl:16])=[CH:4][N:3]=[C:2]([Cl:1])[C:11]=3[CH:10]=[CH:9][CH:8]=2)(=[O:14])=[O:13])[CH2:27]1)[CH3:25])=[O:23])([CH3:20])([CH3:18])[CH3:19].[OH:43][C:2]1[C:11]2[CH:10]=[CH:9][CH:8]=[C:7]([S:12]([N:58]3[CH2:59][CH2:60][C@@H:56]([NH:54][CH3:52])[CH2:57]3)(=[O:14])=[O:13])[C:6]=2[C:5]([Cl:16])=[CH:4][N:3]=1.[ClH:31]