Hydrogen Bromide → HCID 17967160, compound

HRID 1436061Notes

Reaction equation

HRID 1436061 reaction equation
[F:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[CH:9]=[C:10]([CH2:14][NH:15][CH2:16][CH:17]3[CH2:26][CH2:25][C:24]4[C:19](=[C:20]([O:27]C)[CH:21]=[CH:22][CH:23]=4)[O:18]3)[CH:11]=[N:12][CH:13]=2)=[CH:4][CH:3]=1.[BrH:29]>>[BrH:29].[F:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[CH:9]=[C:10]([CH2:14][NH:15][CH2:16][CH:17]3[CH2:26][CH2:25][C:24]4[C:19](=[C:20]([OH:27])[CH:21]=[CH:22][CH:23]=4)[O:18]3)[CH:11]=[N:12][CH:13]=2)=[CH:4][CH:3]=1

Participants

3

Reactant 2

HCID 260Hydrogen BromideHCID 19079368HCID 19079368, compound

Product 1

HCID 17967160HCID 17967160, compound

Procedure

Analoguosly to example 2.1, (2R/S)-2-({[5-(4-fluorophenyl)-pyridin-3ylmethyl]-amino}-methyl)-8-methoxychroman is treated with hydrobromic acid to obtain (2R/S)-2-({[5-(4-fluorophenyl)-pyridin-3ylmethyl]-amino}-methyl)-chroman-8-ol hydrobromide.

Sources & evidence

ORD record
ord-ee2b9029a9ed4ff7a4163f5ae6ecb9f7
Source dataset
uspto-grants-2009_11
Patent number
US07618988B2

Reaction notes

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