Hexane → HCID 24784533, compound

HRID 1436075Notes

Reaction equation

HRID 1436075 reaction equation
[OH:1][CH2:2][C:3]([NH:6][C:7]1[S:8][C:9]2[CH2:19][CH2:18][C:17]3[C:12](=[CH:13][CH:14]=[C:15]([C:20]#[N:21])[CH:16]=3)[C:10]=2[N:11]=1)([CH3:5])[CH3:4].CCCCCC.[C:28](OCC)(=[O:30])C>>[CH3:4][C:3]1([CH3:5])[CH2:2][O:1][C:28](=[O:30])[N:6]1[C:7]1[S:8][C:9]2[CH2:19][CH2:18][C:17]3[C:12](=[CH:13][CH:14]=[C:15]([C:20]#[N:21])[CH:16]=3)[C:10]=2[N:11]=1

Participants

4

Reactant 3

HCID 8058HexaneHCID 8857Ethyl AcetateHCID 86618620HCID 86618620, compound

Product 1

HCID 24784533HCID 24784533, compoundYield 93%

Procedure

In the same manner as described in step 4 of Example 4, replacing 2-fluoro-4-{2-[(2-hydroxy-1,1-dimethyl-ethyl)amino]-1,3-thiazol-4-yl}benzonitrile with 2-[(2-hydroxy-1,1-dimethylethyl)amino]-4,5-dihydronaphtho[1,2-d][1,3]thiazole-7-carbonitrile, prepared in the previous step, and purification of the crude product on silica using a stepwise gradient of 6:1 to 1:1 hexane:ethyl acetate as the eluent gave the title compound (2.7 g, 93%), mp>230° C. (dec.).

Sources & evidence

ORD record
ord-d419307d59a44eb2a277b9e1331f3671
Source dataset
uspto-grants-2009_11
Patent number
US07618989B2

Reaction notes

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