Triphenylphosphine → HCID 57938672, compound

HRID 1436133Notes

Reaction equation

[F:1][C:2]1[CH:18]=[CH:17][C:5]([CH2:6][N:7]2[CH2:12][C:11]([CH3:14])([CH3:13])[O:10][CH:9](O)[C:8]2=[O:16])=[CH:4][CH:3]=1.S(Cl)(Cl)=O.C1(P(C2C=CC=CC=2)C2C=CC=CC=2)C=CC=CC=1.[F:42][C:43]1[CH:44]=[C:45]([CH:48]=[CH:49][C:50]=1[N:51]1[CH:55]=[C:54]([CH3:56])[N:53]=[CH:52]1)[CH:46]=O>>[F:1][C:2]1[CH:18]=[CH:17][C:5]([CH2:6][N:7]2[CH2:12][C:11]([CH3:14])([CH3:13])[O:10]/[C:9](=[CH:46]\[C:45]3[CH:48]=[CH:49][C:50]([N:51]4[CH:55]=[C:54]([CH3:56])[N:53]=[CH:52]4)=[C:43]([F:42])[CH:44]=3)/[C:8]2=[O:16])=[CH:4][CH:3]=1

Participants

Reactant 4

HCID 11776Triphenylphosphine

HCID 24386Thionyl Chloride

HCID 689090194-(4-Fluorobenzyl)-2-hydroxy-6,6-dimethylmorpholin-3-one

HCID 707008423-Fluoro-4-(4-methyl-1H-imidazol-1-yl)benzaldehyde

Product 1

HCID 57938672HCID 57938672, compound

Procedure

44.7 mg of the title compound was obtained from 4-(4-fluorobenzyl)-2-hydroxy-6,6-dimethylmorpholin-3-one, thionyl chloride, triphenylphosphine, and 3-fluoro-4-(4-methyl-1H-imidazol-1-yl)benzaldehyde in the same manner as in Example 7.

Sources & evidence

ORD record: ord-9fda56fd4b964807b9a32df9f5dfe2c2
Source dataset: uspto-grants-2009_11
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07618960B2

Reaction notes

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