Triphenylphosphine → HCID 57938665, compound

HRID 1436135Notes

Reaction equation

[Cl:1][C:2]1[N:7]=[C:6]([CH2:8][N:9]2[CH2:14][CH:13]([CH3:15])[O:12][C@H:11](O)[C:10]2=[O:17])[CH:5]=[CH:4][CH:3]=1.S(Cl)(Cl)=O.C1(P(C2C=CC=CC=2)C2C=CC=CC=2)C=CC=CC=1.[F:41][C:42]1[CH:43]=[C:44]([CH:47]=[CH:48][C:49]=1[N:50]1[CH:54]=[C:53]([CH3:55])[N:52]=[CH:51]1)[CH:45]=O>>[Cl:1][C:2]1[N:7]=[C:6]([CH2:8][N:9]2[CH2:14][C@H:13]([CH3:15])[O:12]/[C:11](=[CH:45]\[C:44]3[CH:47]=[CH:48][C:49]([N:50]4[CH:54]=[C:53]([CH3:55])[N:52]=[CH:51]4)=[C:42]([F:41])[CH:43]=3)/[C:10]2=[O:17])[CH:5]=[CH:4][CH:3]=1

Participants

Reactant 4

HCID 11776Triphenylphosphine

HCID 24386Thionyl Chloride

HCID 707008423-Fluoro-4-(4-methyl-1H-imidazol-1-yl)benzaldehyde

HCID 86612617HCID 86612617, compound

Product 1

HCID 57938665HCID 57938665, compound

Procedure

24.3 mg of the title compound was obtained from (S)-4-(6-chloropyridin-2-ylmethyl)-2-hydroxy-6-methylmorpholin-3-one, thionyl chloride, triphenylphosphine, and 3-fluoro-4-(4-methyl-1H-imidazol-1-yl)benzaldehyde in the same manner as in Example 15.

Sources & evidence

ORD record: ord-479fb71170f84ae79e9f32a7955fb09e
Source dataset: uspto-grants-2009_11
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07618960B2

Reaction notes

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