反应详情

温度

-15 °C

LAH (483 mg) was added to a solution of ethyl (2R,5S)-5-(3,4,5-trifluorophenyl)pyrrolidine-2-carboxylate (2.91 g) in THF (50 mL) at −15° C. over one hour. The reaction solution was stirred at −15° C. for 19 hours. Water (0.5 mL), a 5 N sodium hydroxide solution (0.5 mL), and water (1.5 mL) were sequentially added to the reaction solution, and the mixture was stirred at room temperature for 30 minutes. The reaction solution was filtered through celite, and the filtrate was concentrated under reduced pressure to obtain 2.4 g of the title compound. The property values of the compound are as follows.

1. stirringthe mixture was stirred at room temperature for 30 minutes
2. filtrationThe reaction solution was filtered through celite
3. concentrationthe filtrate was concentrated under reduced pressure