Ethanolamine → HCID 57938786, compound

HRID 1436255Notes

Reaction equation

HRID 1436255 reaction equation
Cl[C:2]1[N:11]=[C:10]([N:12]([C:14]2[CH:15]=[N:16][C:17]([O:20][CH3:21])=[CH:18][CH:19]=2)[CH3:13])[C:9]2[C:4](=[CH:5][CH:6]=[CH:7][CH:8]=2)[N:3]=1.[CH2:22]([CH2:24][NH2:25])[OH:23]>>[OH:23][CH2:22][CH2:24][NH:25][C:2]1[N:11]=[C:10]([N:12]([C:14]2[CH:15]=[N:16][C:17]([O:20][CH3:21])=[CH:18][CH:19]=2)[CH3:13])[C:9]2[C:4](=[CH:5][CH:6]=[CH:7][CH:8]=2)[N:3]=1

Participants

3

Reactant 2

HCID 700EthanolamineHCID 11558497(2-chloro-quinazolin-4-yl)-(6-methoxy-pyridin-3-yl)-methylamine

Product 1

HCID 57938786HCID 57938786, compound

Procedure

The title compound was prepared from (2-chloro-quinazolin-4-yl)-(6-methoxy-pyridin-3-yl)-methyl-amine (12 mg, 0.040 mmol) and ethanolamine (28 μl) by a procedure similar to example 10 and was isolated as off white solid (8 mg, 66%). 1H NMR (CDCl3): 8.03 (brd, J=3.0 Hz, 1H), 7.47-7.35 (m, 3H), 6.91 (brd, J=8.7 Hz, 1H), 6.78-6.73 (m, 2H), 5.56 (brs, 1H), 3.94 (s, 3H), 3.93-3.90 (m, 2H), 3.70-3.56 (m, 2H), 3.48 (s, 3H).

Sources & evidence

ORD record
ord-95e53b40e7b74f54b1d65e686bdf1213
Source dataset
uspto-grants-2009_11
Patent number
US07618975B2

Reaction notes

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