Ammonia → HCID 57938806, compound

HRID 1436256Notes

Reaction equation

HRID 1436256 reaction equation
Cl[C:2]1[N:11]=[C:10]([N:12]([C:14]2[CH:15]=[N:16][C:17]([O:20][CH3:21])=[CH:18][CH:19]=2)[CH3:13])[C:9]2[C:4](=[CH:5][CH:6]=[CH:7][CH:8]=2)[N:3]=1.[NH3:22]>CO>[CH3:21][O:20][C:17]1[N:16]=[CH:15][C:14]([N:12]([CH3:13])[C:10]2[C:9]3[C:4](=[CH:5][CH:6]=[CH:7][CH:8]=3)[N:3]=[C:2]([NH2:22])[N:11]=2)=[CH:19][CH:18]=1

Participants

4

Reactant 2

HCID 222AmmoniaHCID 11558497(2-chloro-quinazolin-4-yl)-(6-methoxy-pyridin-3-yl)-methylamine

Product 1

HCID 57938806HCID 57938806, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

The title compound was prepared from (2-chloro-quinazolin-4-yl)-(6-methoxy-pyridin-3-yl)-methylamine (10 mg, 0.030 mmol) and 7 M ammonia in methanol (1 mL) by a procedure similar to example 10 (3 mg, 30%). 1H NMR (CDCl3): 8.04 (dd, J=2.9, 0.6 Hz, 1H), 7.49-7.43 (m, 2H), 7.39 (dd, J=5.7 and 2.7 Hz, 1H), 6.92 (brd, J=8.4 Hz, 1H), 6.85-6.78 (m, 2H), 5.65 (s, 2H), 3.96 (s, 3H), 3.54 (s, 3H).

Sources & evidence

ORD record
ord-d1a6bae7394d4a68a4264e555fd056e6
Source dataset
uspto-grants-2009_11
Patent number
US07618975B2

Reaction notes

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