Piperazine → 3-(3,4-Dimethoxyphenyl)-7-[2-hydroxy-3-(piperazin-1-yl)propoxy]-4H-chromen-4-one

Participants

Reaction Steps

A mixture of compound 4 (obtained from example 2) (0.35 g, 1 mmol), piperazine (0.43 g, 5 mmol), and ethanol (30 mL) was refluxed for 6 hrs (TLC monitoring). After removal of solvent in vaccuo, the residue was treated with H2O (50 mL). The resulting precipitate was collected and purified by column chromatography (MeOH/CH2Cl2=1:25) to give the title compound 6b (0.25 g, 56% yield). M.p.: 84-85° C.

Provenance & Evidence