反应详情

A mixture of compound 4 (obtained from example 2) (0.35 g, 1 mmol), piperazine (0.43 g, 5 mmol), and ethanol (30 mL) was refluxed for 6 hrs (TLC monitoring). After removal of solvent in vaccuo, the residue was treated with H2O (50 mL). The resulting precipitate was collected and purified by column chromatography (MeOH/CH2Cl2=1:25) to give the title compound 6b (0.25 g, 56% yield). M.p.: 84-85° C.

1. temperaturewas refluxed for 6 hrs (TLC monitoring)
2. customAfter removal of solvent in vaccuo
3. additionthe residue was treated with H2O (50 mL)
4. customThe resulting precipitate was collected
5. custompurified by column chromatography (MeOH/CH2Cl2=1:25)