2,2-Difluoroethan-1-ol → 1-[6-(2-Fluoroethoxy)pyridin-3-yl]ethanamine

HRID 1436338Notes

Reaction equation

HRID 1436338 reaction equation
[F:1][C:2](F)(F)[CH2:3][O:4][C:5]1[N:10]=[CH:9][C:8]([CH:11]([NH2:13])[CH3:12])=[CH:7][CH:6]=1.ClC1C=CC(C#N)=CN=1.FC(F)CO>>[F:1][CH2:2][CH2:3][O:4][C:5]1[N:10]=[CH:9][C:8]([CH:11]([NH2:13])[CH3:12])=[CH:7][CH:6]=1

Participants

4

Reactant 3

HCID 1361872,2-Difluoroethan-1-olHCID 51520946-Chloro-3-pyridinecarbonitrileHCID 586291003-Pyridinemethanamine, alpha-methyl-6-(2,2,2-trifluoroethoxy)-

Product 1

HCID 586290951-[6-(2-Fluoroethoxy)pyridin-3-yl]ethanamine

Procedure

The title compound was synthesised according to the 2-step procedure described for the synthesis of 1-[6-(2,2,2-trifluoroethoxy)pyridin-3-yl]ethanamine starting from 6-chloronicotinonitrile and 2,2-difluoroethanol.

Sources & evidence

ORD record
ord-3390fb25ed9842afa459c4970a884e6d
Source dataset
uspto-grants-2009_11
Patent number
US07618993B2

Reaction notes

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