HuagongsheHuagongshe Chemistry Print Report · For research reference only
2,2-Difluoroethan-1-ol → 1-[6-(2-Fluoroethoxy)pyridin-3-yl]ethanamine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2,2-Difluoroethan-1-ol | HCID 136187 | — |
| Reactant | 6-Chloro-3-pyridinecarbonitrile | HCID 5152094 | — |
| Reactant | 3-Pyridinemethanamine, alpha-methyl-6-(2,2,2-trifluoroethoxy)- | HCID 58629100 | — |
| Product | 1-[6-(2-Fluoroethoxy)pyridin-3-yl]ethanamine | HCID 58629095 | — |
Reaction Steps
The title compound was synthesised according to the 2-step procedure described for the synthesis of 1-[6-(2,2,2-trifluoroethoxy)pyridin-3-yl]ethanamine starting from 6-chloronicotinonitrile and 2,2-difluoroethanol.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07618993B2 |
| Source dataset | uspto-grants-2009_11 |
| ORD ID | ord-3390fb25ed9842afa459c4970a884e6d |
| Source note | uspto-grants-2009_11 |