Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Formaldehyde | HCID 712 | — |
| Reactant | HCID 69016228 | HCID 69016228 | — |
| Solvent | Hydrochloric Acid | HCID 313 | — |
| Solvent | Water | HCID 962 | — |
| Product | HCID 69014752 | HCID 69014752 | 75% |
Reaction Steps
Slurry 2-bromo-5-hydroxy-(D)-phenylalanine (1.87 g, 0.00719 mol) in 0.05 M hydrochloric acid (10.7 mL) and add 37% formaldehyde solution in water (1.02 mL). Heat at 90° C. for one hour. Cool to room temperature, filter, and wash with water (2×) and acetone (2×) and dry in a vacuum oven to give the desired product (1.53 g, 75%) as a light pink solid.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US07618978B2 |
|---|
| Source dataset | uspto-grants-2009_11 |
|---|
| ORD ID | ord-928166a0e745470bbadb99328a124ba2 |
|---|
| Source note | uspto-grants-2009_11 |
|---|
