Formaldehyde → HCID 69014752, compound

HRID 1436486Notes

Reaction equation

HRID 1436486 reaction equation
[Br:1][C:2]1[CH:13]=[CH:12][C:11]([OH:14])=[CH:10][C:3]=1[CH2:4][C@H:5]([C:7]([OH:9])=[O:8])[NH2:6].[CH2:15]=O>Cl.O>[Br:1][C:2]1[CH:13]=[CH:12][C:11]([OH:14])=[C:10]2[C:3]=1[CH2:4][C@H:5]([C:7]([OH:9])=[O:8])[NH:6][CH2:15]2

Participants

5

Reactant 2

HCID 712FormaldehydeHCID 69016228HCID 69016228, compound

Product 1

HCID 69014752HCID 69014752, compoundYield 75%

Reagents, catalysts & solvents 2

HCID 313Hydrochloric AcidSolventHCID 962WaterSolvent

Conditions

Temperature
90 °C

Procedure

Slurry 2-bromo-5-hydroxy-(D)-phenylalanine (1.87 g, 0.00719 mol) in 0.05 M hydrochloric acid (10.7 mL) and add 37% formaldehyde solution in water (1.02 mL). Heat at 90° C. for one hour. Cool to room temperature, filter, and wash with water (2×) and acetone (2×) and dry in a vacuum oven to give the desired product (1.53 g, 75%) as a light pink solid.

Workup

  1. temperatureCool to room temperature
  2. filtrationfilter
  3. washwash with water (2×) and acetone (2×)
  4. customdry in a vacuum oven

Sources & evidence

ORD record
ord-928166a0e745470bbadb99328a124ba2
Source dataset
uspto-grants-2009_11
Patent number
US07618978B2

Reaction notes

Loading…