反应详情

温度

99 °C

Add to a 300 mL of autoclave reactor (s)-(+)-2-sec-butylamino-6-chloro-isonicotinic acid methyl ester (12.46 g, 0.05134 mol), bis(dibenzylideneacetone)palladium (0) (2.35 g, 0.002567 mol), 2-di-tert-butylphosphino biphenyl (1.53 g, 0.005134 mol) and sodium methanesulfonamide (12.02 g, 0.1027 mol) in toluene (250 mL). Flush with nitrogen 3 times and heat to 99° C. for 24 h. Filter and dissolve the filter cake in water (400 mL). Extract the aqueous layer with chloroform (3×200 mL), dry (magnesium sulfate) and concentrate. Dissolve the crude product in dichloromethane (20 mL) and precipitate out by adding hexanes (400 mL) to give a solid (7.18 g, 46%).

1. customFlush with nitrogen 3 times
2. filtrationFilter
3. dissolutiondissolve the filter cake in water (400 mL)
4. extractionExtract the aqueous layer with chloroform (3×200 mL)
5. dry with materialdry (magnesium sulfate)
6. concentrationconcentrate
7. dissolutionDissolve the crude product in dichloromethane (20 mL)
8. customprecipitate out
9. additionby adding hexanes (400 mL)