反应详情

Heat a mixture of (S)-(+)-2-sec-butylamino-6-(methanesulfonyl-methylamino)-isonicotinic acid methyl ester (12.66 g, 0.04014 mol) and potassium hydroxide (2.7 g, 0.04817 mol, 1.2 eq) until dissolved. Dilute with water (62 mL) and was heat to reflux for 3 h. Cool to room temperature and add 1 N HCl (8 mL). Concentrate and add dichloromethane (300 mL) and stir well. Filter and concentrate filtrate to give the title compound as a yellow solid (13.62 g, 100%).

1. temperatureHeat
2. dissolutionuntil dissolved
3. temperaturewas heat
4. temperatureto reflux for 3 h
5. concentrationConcentrate
6. additionadd dichloromethane (300 mL)
7. filtrationFilter
8. concentrationconcentrate filtrate