反应详情

温度

130 °C

Charge a pressure tube with sodium iodide (734 mg, 4.9 mmol), copper iodide (23 mg, 0.12 mmol), trans-N,N′-dimethyl-cyclohexane-1,2-diamine (34 mg, 0.24 mmol) dissolved in 0.5 ml of pentanol, and 1-bromo-2-(3-methyl-butyl)-benzene dissolved in 0.5 ml of pentanol. Purge with nitrogen, cap the tube, and heat at 130° C. for 3 days. Subject to silica gel chromatography, eluting with hexane to obtain the desired compound as a colorless liquid (587 mg, 84%).

1. customPurge with nitrogen
2. customcap the tube
3. washeluting with hexane