関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | Sodium Iodide | HCID 5238 | — |
| 反応物 | trans-N,N'-dimethyl-1,2-cyclohexanediamine | HCID 2733821 | — |
| 反応物 | 1-Bromo-2-(3-methyl-butyl)-benzene | HCID 21063769 | — |
| 触媒 | Copper iodide | HCID 83717 | — |
| 溶媒 | 1-Pentanol | HCID 6276 | — |
| 生成物 | 1-Iodo-2-(3-methyl-butyl)-benzene | HCID 54130445 | 84% |
反応手順
Charge a pressure tube with sodium iodide (734 mg, 4.9 mmol), copper iodide (23 mg, 0.12 mmol), trans-N,N′-dimethyl-cyclohexane-1,2-diamine (34 mg, 0.24 mmol) dissolved in 0.5 ml of pentanol, and 1-bromo-2-(3-methyl-butyl)-benzene dissolved in 0.5 ml of pentanol. Purge with nitrogen, cap the tube, and heat at 130° C. for 3 days. Subject to silica gel chromatography, eluting with hexane to obtain the desired compound as a colorless liquid (587 mg, 84%).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 特許番号 | US07618978B2 |
|---|
| 出典データセット | uspto-grants-2009_11 |
|---|
| ORD ID | ord-b98691b47b314fccb669e9c3cb4fe89c |
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| 出典メモ | uspto-grants-2009_11 |
|---|
