2-(Dibenzylamino)-3-(3,5-difluorophenyl)-propanal → 2-(S)-[2-(S)-Amino-3-(3,5-difluoro-phenyl)-1-(S)-hydroxy-propyl]-4-[2-(3-methyl-butyl)-phenyl]-3-oxo-piperazine-1-carboxylic acid tert-butyl ester

Participants

Role	Name	HCID	Charge
Reactant	2-(Dibenzylamino)-3-(3,5-difluorophenyl)-propanal	HCID 58622433	—
Reactant	4-[2-(3-Methyl-butyl)-phenyl]-3-oxo-piperazine-1-carboxylic acid tert-butyl ester	HCID 69017615	—
Product	2-(S)-[2-(S)-Amino-3-(3,5-difluoro-phenyl)-1-(S)-hydroxy-propyl]-4-[2-(3-methyl-butyl)-phenyl]-3-oxo-piperazine-1-carboxylic acid tert-butyl ester	HCID 69015910	—

Reaction Steps

The title is prepared by reacting 4-[2-(3-methyl-butyl)-phenyl]-3-oxo-piperazine-1-carboxylic acid tert-butyl ester with 2-(dibenzylamino)-3-(3,5-difluorophenyl)-propanal essentially as described in Preparation 41.

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US07618978B2
Source dataset	uspto-grants-2009_11
ORD ID	ord-1a3a372096624bfaa657a10174cfa929
Source note	uspto-grants-2009_11