huagongshe.com
HRID1436531

反应详情

EQUATION

反应方程式

HRID 1436531 的结构方程式

REACTANTS

反应物

3
结构：Cl
HCID313

Hydrochloric Acid

ClH

结构：[Na+].[OH-]
HCID14798

Sodium Hydroxide

HNaO

结构：CC[C@H](C)Nc1cc(C(=O)OC)cc(N(C)S(=O)(=O)C2CC2)n1
HCID68815532

未命名化合物

PRODUCTS

生成物

1
结构：CC[C@H](C)Nc1cc(C(=O)O)cc(N(C)S(=O)(=O)C2CC2)n1
HCID68816222

未命名化合物

AUXILIARIES

试剂、催化剂与溶剂

1
结构：CO
溶剂HCID887

Methanol

CH4O

PROCEDURE

实验过程

Dissolve (S)-2-sec-butylamino-6-(cyclopropanesulfonyl-methylamino)-isonicotinic acid methyl ester (600 mg, 1.97 mmol) in methanol (18 mL). Slowly add 2 N NaOH (3 mL) and stir overnight at room temperature. Acidify the mixture to about pH=6 with 5 N HCl and concentrate. Dilute with ethyl acetate (30 mL) and wash the organic layer with saturated aqueous sodium chloride solution, dry (magnesium sulfate) and concentrate to give the title compound.

WORKUP

后处理

  1. concentrationconcentrate
  2. additionDilute with ethyl acetate (30 mL)
  3. washwash the organic layer with saturated aqueous sodium chloride solution
  4. dry with materialdry (magnesium sulfate)
  5. concentrationconcentrate