HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrochloric Acid → (S)-2-sec-Butylamino-6-(2-oxopropyl)-isonicotinic acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | Lithium Hydroxide | HCID 3939 | — |
| Reactant | (S)-2-sec-Butylamino-6-(2-oxopropyl)-isonicotinic acid methyl ester | HCID 68814857 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | (S)-2-sec-Butylamino-6-(2-oxopropyl)-isonicotinic acid | HCID 68818395 | — |
Reaction Steps
Dissolve (S)-2-sec-butylamino-6-(2-oxopropyl)-isonicotinic acid methyl ester (50 mg, 0.19 mmol) in THF (2 mL). Slowly add 1 N lithium hydroxide (0.28 mL) and stir overnight at room temperature. Acidify the mixture to about pH=6 by 5 N HCl and concentrate to near dryness. Dilute with ethyl acetate (10 mL) and wash the organic layer with saturated aqueous sodium chloride. Dry (magnesium sulfate) and concentrate to give the title compound as a solid.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07618978B2 |
| Source dataset | uspto-grants-2009_11 |
| ORD ID | ord-6bfd5881243a48289e6d4c1d155b2a54 |
| Source note | uspto-grants-2009_11 |