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HRID1436544

反应详情

EQUATION

反应方程式

HRID 1436544 的结构方程式

REACTANTS

反应物

3
结构：Cl
HCID313

Hydrochloric Acid

ClH

结构：[Li+].[OH-]
HCID3939

Lithium hydroxide anhydrous

HLiO

结构：CC[C@H](C)Nc1cc(C(=O)OC)cc(CC(C)=O)n1
HCID68814857

未命名化合物

PRODUCTS

生成物

1
结构：CC[C@H](C)Nc1cc(C(=O)O)cc(CC(C)=O)n1
HCID68818395

未命名化合物

AUXILIARIES

试剂、催化剂与溶剂

1
结构：C1CCOC1
溶剂HCID8028

Tetrahydrofuran

C4H8O

PROCEDURE

实验过程

Dissolve (S)-2-sec-butylamino-6-(2-oxopropyl)-isonicotinic acid methyl ester (50 mg, 0.19 mmol) in THF (2 mL). Slowly add 1 N lithium hydroxide (0.28 mL) and stir overnight at room temperature. Acidify the mixture to about pH=6 by 5 N HCl and concentrate to near dryness. Dilute with ethyl acetate (10 mL) and wash the organic layer with saturated aqueous sodium chloride. Dry (magnesium sulfate) and concentrate to give the title compound as a solid.

WORKUP

后处理

  1. concentrationconcentrate to near dryness
  2. additionDilute with ethyl acetate (10 mL)
  3. washwash the organic layer with saturated aqueous sodium chloride
  4. dry with materialDry (magnesium sulfate)
  5. concentrationconcentrate