反应详情

Treat a solution of (S)-2-sec-butylamino-6-(2-methyl-2H-tetrazol-5-yl)-isonicotinic acid methyl ester (250 mg, 0.86 mmol) in methanol (5 mL) with 2 N NaOH (0.64 mL, 1.29 mmol). Stir at room temperature overnight, acidify the reaction to about pH=3 using 1 N HCl. Extract the reaction mixture with ethyl acetate (3×25 mL). Wash the combined organic layers with saturated aqueous sodium chloride, dry (sodium sulfate) and concentrate to give the title compound.

1. customthe reaction to about pH=3
2. extractionExtract the reaction mixture with ethyl acetate (3×25 mL)
3. washWash the combined organic layers with saturated aqueous sodium chloride
4. dry with materialdry (sodium sulfate)
5. concentrationconcentrate