Hydrochloric Acid → HCID 28400021, compound

HRID 1436595Notes

Reaction equation

HRID 1436595 reaction equation
C[O:2][C:3](=[O:15])[C:4]1[CH:9]=[CH:8][N:7]=[C:6]([NH:10][C@H:11]([CH2:13][CH3:14])[CH3:12])[CH:5]=1.[OH-].[Na+].Cl>CO>[C@@H:11]([NH:10][C:6]1[CH:5]=[C:4]([CH:9]=[CH:8][N:7]=1)[C:3]([OH:15])=[O:2])([CH2:13][CH3:14])[CH3:12]

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 14798Sodium HydroxideHCID 68814422HCID 68814422, compound

Product 1

HCID 28400021HCID 28400021, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

Treat a solution of (S)-2-sec-butylamino-isonicotinic acid methyl ester (2.69 g, 12.5 mmol) in methanol (35 mL) with 1 N NaOH (15 mL, 15 mmol) at room temperature for 5 hr. Acidify to about pH=3 with 1 N HCl. Concentrate and redissolve the residue in a 1:1 CH3CN:water solution and lyophilize to give the title compound.

Workup

  1. concentrationConcentrate
  2. dissolutionredissolve the residue in a 1:1 CH3CN

Sources & evidence

ORD record
ord-805eb0f2609e4605b07933dc3b843492
Source dataset
uspto-grants-2009_11
Patent number
US07618978B2

Reaction notes

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