Chlorosulfonic acid → 3-Bromo-4-fluoro-5-(chlorosulfonyl)benzoic acid

HRID 1436653Notes

Reaction equation

HRID 1436653 reaction equation
[Br:1][C:2]1[CH:3]=[C:4]([CH:8]=[CH:9][C:10]=1[F:11])[C:5]([OH:7])=[O:6].[Cl:12][S:13](O)(=[O:15])=[O:14]>>[Br:1][C:2]1[CH:3]=[C:4]([CH:8]=[C:9]([S:13]([Cl:12])(=[O:15])=[O:14])[C:10]=1[F:11])[C:5]([OH:7])=[O:6]

Participants

3

Reactant 2

HCID 24638Chlorosulfonic acidHCID 705093-Bromo-4-fluorobenzoic acid

Product 1

HCID 509984803-Bromo-4-fluoro-5-(chlorosulfonyl)benzoic acid

Procedure

Heat 3-bromo-4-fluorobenzoic acid (6.25 g, 26.2 mmol) in chlorosulfonic acid (15 mL) at 125° C. for 120 h. Cool to room temperature and add dropwise to about 125 mL ice water. Collect the filtered solid as the title compound.

Workup

  1. customCollect the filtered solid as the title compound

Sources & evidence

ORD record
ord-482e5b46ba1b43518b84a133d311a127
Source dataset
uspto-grants-2009_11
Patent number
US07618978B2

Reaction notes

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