反应详情

Dissolve N-Methyl-N-propyl-5-thiazol-2-yl-isophthalamic acid methyl ester (150 mg, 0.47 mmol) in methanol (6 mL). Add dropwise 2 N NaOH (0.3 mL) and stir overnight at room temperature. Acidify the mixture to about pH=6 by 5 N HCl and concentrate to near dryness. Dilute with ethyl acetate (20 mL) and wash the organic layer with saturated aqueous sodium chloride solution, dry (magnesium sulfate) and concentrate to give the title compound as an oil.

1. concentrationconcentrate to near dryness
2. additionDilute with ethyl acetate (20 mL)
3. washwash the organic layer with saturated aqueous sodium chloride solution
4. dry with materialdry (magnesium sulfate)
5. concentrationconcentrate