HCID 68816243, compound → HCID 68816405, compound

HRID 1436700Notes

Reaction equation

HRID 1436700 reaction equation
[CH3:1][O:2][C:3](=[O:22])[C:4]1[CH:16]=[C:15]([C:17](=[O:21])[C:18]([CH3:20])=[CH2:19])[CH:14]=[C:6]([C:7]([N:9]([CH3:13])[CH2:10][CH2:11][CH3:12])=[O:8])[CH:5]=1>C(OCC)(=O)C.[Ni]>[CH3:1][O:2][C:3](=[O:22])[C:4]1[CH:16]=[C:15]([CH:17]([OH:21])[CH:18]([CH3:19])[CH3:20])[CH:14]=[C:6]([C:7]([N:9]([CH3:13])[CH2:10][CH2:11][CH3:12])=[O:8])[CH:5]=1

Participants

4

Reactant 1

HCID 68816243HCID 68816243, compound

Product 1

HCID 68816405HCID 68816405, compound

Reagents, catalysts & solvents 2

HCID 935NickelCatalystHCID 8857Ethyl AcetateSolvent

Procedure

Dissolve N-methyl-5-(2-methylacryloyl)-N-propyl-isophthalamic acid methyl ester (80 mg, 0.26 mmol) in ethyl acetate (25 mL) under nitrogen. Add Raney® nickel (100 mg) and hydrogenate the reaction for 2 h at room temperature under an atmosphere of hydrogen gas (40 psi). Filter the reaction and concentrate to give the crude title product.

Workup

  1. customthe reaction for 2 h at room temperature under an atmosphere of hydrogen gas (40 psi)
  2. filtrationFilter
  3. customthe reaction
  4. concentrationconcentrate

Sources & evidence

ORD record
ord-9e10a151dac642cb9b43f84cd2f59528
Source dataset
uspto-grants-2009_11
Patent number
US07618978B2

Reaction notes

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