HCID 57938828, compound → HCID 69015996, compound

HRID 1436736Notes

Reaction equation

HRID 1436736 reaction equation
C(OC([N:8]1[CH2:13][CH2:12][CH2:11][CH2:10][C@@H:9]1[C@@H:14]([OH:29])[C@@H:15]([NH:25][C:26](=[O:28])[CH3:27])[CH2:16][C:17]1[CH:22]=[C:21]([F:23])[CH:20]=[C:19]([F:24])[CH:18]=1)=O)(C)(C)C>Cl>[F:24][C:19]1[CH:18]=[C:17]([CH:22]=[C:21]([F:23])[CH:20]=1)[CH2:16][C@H:15]([NH:25][C:26](=[O:28])[CH3:27])[C@H:14]([OH:29])[C@H:9]1[CH2:10][CH2:11][CH2:12][CH2:13][NH:8]1

Participants

3

Reactant 1

HCID 57938828HCID 57938828, compound

Product 1

HCID 69015996HCID 69015996, compound

Reagents, catalysts & solvents 1

HCID 313Hydrochloric AcidSolvent

Procedure

Dissolve (R)-2-[(1S,2S)-2-Acetylamino-3-(3,5-difluorophenyl)-1-hydroxypropyl]-piperidine-1-carboxylic acid tert-butyl ester (0.085 g, 0.21 mmol) in hydrogen chloride (4 M in 1,4-dioxane, 3 mL). Stir 1 h and concentrate to give the title compound as a foam 10 (0.077 g, 100%).

Workup

  1. concentrationconcentrate

Sources & evidence

ORD record
ord-8e9bb109114642418205dd642bd950bd
Source dataset
uspto-grants-2009_11
Patent number
US07618978B2

Reaction notes

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