HCID 57938740, compound → HCID 57938723, compound

HRID 1436771Notes

Reaction equation

HRID 1436771 reaction equation
[OH:1][C:2]1([C:26]2[CH:31]=[CH:30][CH:29]=[CH:28][CH:27]=2)[CH2:7][CH2:6][N:5]([C:8]([C@@:10]2([CH:23]([CH3:25])[CH3:24])[CH2:14][CH2:13][C@@H:12]([NH:15]C(=O)OC(C)(C)C)[CH2:11]2)=[O:9])[CH2:4][CH2:3]1>Cl.CCOCC.CO>[NH2:15][C@@H:12]1[CH2:13][CH2:14][C@@:10]([C:8]([N:5]2[CH2:4][CH2:3][C:2]([C:26]3[CH:31]=[CH:30][CH:29]=[CH:28][CH:27]=3)([OH:1])[CH2:7][CH2:6]2)=[O:9])([CH:23]([CH3:24])[CH3:25])[CH2:11]1

Participants

5

Reactant 1

HCID 57938740HCID 57938740, compound

Product 1

HCID 57938723HCID 57938723, compound

Reagents, catalysts & solvents 3

HCID 887MethanolCatalystHCID 313Hydrochloric AcidSolventHCID 3283Diethyl EtherSolvent

Procedure

tert-Butyl {(1R,3S)-3-[(4-hydroxy-4-phenylpiperidin-1-yl)carbonyl]-3-isopropyl-cyclopentyl}carbamate (0.30 g, 0.70 mmol) was dissolved in a 2.0 M solution of HCl in ether (10 mL). After being stirred for 3.5 h, a few drops of MeOH was added to get a clear solution. The mixture was concentrated to give an oil. The crude product was used in the next reaction without purification. MS calculated for C20H30N2O2: (M+H)331; found 331.2.

Workup

  1. customto get a clear solution
  2. concentrationThe mixture was concentrated
  3. customto give an oil

Sources & evidence

ORD record
ord-583602d9ab8b451880f4debcfdabc2fd
Source dataset
uspto-grants-2009_11
Patent number
US07618970B2

Reaction notes

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